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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 3
1992 2
1993 7
1994 22
1995 41
1996 52
1997 61
1998 65
1999 87
2000 82
2001 92
2002 84
2003 81
2004 81
2005 64
2006 68
2007 51
2008 67
2009 58
2010 57
2011 64
2012 43
2013 64
2014 59
2015 62
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1,601 results

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Page 1
Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation.
de Boor S, Knyphausen P, Kuhlmann N, Wroblowski S, Brenig J, Scislowski L, Baldus L, Nolte H, Krüger M, Lammers M. de Boor S, et al. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3679-88. doi: 10.1073/pnas.1505995112. Epub 2015 Jun 29. Proc Natl Acad Sci U S A. 2015. PMID: 26124124 Free PMC article.
Ran is a small GTP-binding protein of the Ras superfamily regulating fundamental cellular processes: nucleo-cytoplasmic transport, nuclear envelope formation and mitotic spindle assembly. ...Here, we show that lysine acetylation interferes with essenti …
Ran is a small GTP-binding protein of the Ras superfamily regulating fundamental cellular processes: nucleo-cyto …
Microtubule binding of the human augmin complex is directly controlled by importins and Ran-GTP.
Ustinova K, Ruhnow F, Gili M, Surrey T. Ustinova K, et al. J Cell Sci. 2023 Jun 15;136(12):jcs261096. doi: 10.1242/jcs.261096. Epub 2023 Jun 26. J Cell Sci. 2023. PMID: 37357828 Free PMC article.
Here, we present the in vitro reconstitution of Ran-GTP-regulated microtubule binding of the human augmin complex. We demonstrate that importins directly bind to augmin, which prevents augmin from binding to microtubules. Ran-GTP relieves …
Here, we present the in vitro reconstitution of Ran-GTP-regulated microtubule binding of the human augmin complex. We d …
Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.
Nemergut ME, Lindsay ME, Brownawell AM, Macara IG. Nemergut ME, et al. J Biol Chem. 2002 May 17;277(20):17385-8. doi: 10.1074/jbc.C100620200. Epub 2002 Apr 3. J Biol Chem. 2002. PMID: 11932251 Free article.
Ran-binding protein 3 (RanBP3) is an approximately 55-kDa protein that functions as a cofactor for Crm1-mediated nuclear export. ...This interaction was stimulated by the addition of Ran; moreover, Ran.GDP, Ran.GTP, and R …
Ran-binding protein 3 (RanBP3) is an approximately 55-kDa protein that functions as a cofactor for Crm1-mediated …
Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram S, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R, Yao X, Wu J, Shi Y. Bao X, et al. J Mol Cell Biol. 2018 Feb 1;10(1):18-32. doi: 10.1093/jmcb/mjx045. J Mol Cell Biol. 2018. PMID: 29040603 Free PMC article.
Our structure-guided functional analyses revealed that Mog1 competes with RCC1 for Ran binding in a GTP/GDP-dependent manner. Biochemical characterization demonstrated that Mog1-bound Ran prevents RCC1 binding and subsequent GTP loading. …
Our structure-guided functional analyses revealed that Mog1 competes with RCC1 for Ran binding in a GTP/GDP-dependent m …
Tyr39 of ran preserves the Ran.GTP gradient by inhibiting GTP hydrolysis.
Brucker S, Gerwert K, Kötting C. Brucker S, et al. J Mol Biol. 2010 Aug 6;401(1):1-6. doi: 10.1016/j.jmb.2010.05.068. Epub 2010 Jun 2. J Mol Biol. 2010. PMID: 20609434
Ran regulates nuclear transport. In order to maintain a gradient of excess Ran.GTP within the nucleoplasm and excess Ran.GDP within the cytoplasm, the hydrolysis of Ran.GTP in the nucleoplasm should be prevented, whereas in the cytoplasm, …
Ran regulates nuclear transport. In order to maintain a gradient of excess Ran.GTP within the nucleoplasm and excess …
RAN GTPase as a target for cancer therapy: Ran binding proteins.
Doherty KJ, McKay C, Chan KK, El-Tanani MK. Doherty KJ, et al. Curr Mol Med. 2011 Nov;11(8):686-95. doi: 10.2174/156652411797536688. Curr Mol Med. 2011. PMID: 21902650 Review.
In the absence of Ran binding proteins, Ran is expected to remain locked up in non-productive complexes with importins and is effectively removed from the system. Thus, Ran binding proteins present as a logical molecular target for the inhibitio …
In the absence of Ran binding proteins, Ran is expected to remain locked up in non-productive complexes with importins …
XMog1, a nuclear ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe mog1p that co-operates with RanBP1 to control generation of Ran-GTP.
Nicolás FJ, Moore WJ, Zhang C, Clarke PR. Nicolás FJ, et al. J Cell Sci. 2001 Aug;114(Pt 16):3013-23. doi: 10.1242/jcs.114.16.3013. J Cell Sci. 2001. PMID: 11686304
By screening a Xenopus oocyte cDNA library for Ran-GTP-binding proteins using the two-hybrid system of co-expression in yeast, we identified XMog1, a 20.4 kDa polypeptide related to Mog1p in Saccharomyces cerevisiae and similar gene products in Schizosaccharo …
By screening a Xenopus oocyte cDNA library for Ran-GTP-binding proteins using the two-hybrid system of co-expression in …
Induction of Ran GTP drives ciliogenesis.
Fan S, Whiteman EL, Hurd TW, McIntyre JC, Dishinger JF, Liu CJ, Martens JR, Verhey KJ, Sajjan U, Margolis B. Fan S, et al. Mol Biol Cell. 2011 Dec;22(23):4539-48. doi: 10.1091/mbc.E11-03-0267. Epub 2011 Oct 12. Mol Biol Cell. 2011. PMID: 21998203 Free PMC article.
The Ran-binding protein 1 (RanBP1), which indirectly accelerates Ran GTP Ran GDP hydrolysis and promotes the dissociation of the Ran/importin complex, also localizes to basal bodies and cilia. To confirm the crucial link between …
The Ran-binding protein 1 (RanBP1), which indirectly accelerates Ran GTP Ran GDP hydrolysis and pr …
Random mutagenesis and functional analysis of the Ran-binding protein, RanBP1.
Petersen C, Orem N, Trueheart J, Thorner JW, Macara IG. Petersen C, et al. J Biol Chem. 2000 Feb 11;275(6):4081-91. doi: 10.1074/jbc.275.6.4081. J Biol Chem. 2000. PMID: 10660567 Free article.
Several proteins that recognize Ran in its GTP-bound state (Ran x GTP) possess a conserved Ran-binding domain (RanBD). Ran-binding protein-1 (RanBP1) has a single RanBD and is required for RanGAP-mediated GTP h …
Several proteins that recognize Ran in its GTP-bound state (Ran x GTP) possess a conserved Ran-binding …
1,601 results